Hormonal
Significant weight loss in morbidly obese patients induces a decrease in circulating inflammatory proteins CRP and IL-6, which is associated with an improvement in insulin resistance.
For morbidly obese individuals, significant weight loss—whether through surgical intervention or substantial lifestyle changes—can significantly reduce chronic inflammation (measured by CRP and IL-6). This reduction in inflammation is linked to improved insulin sensitivity, suggesting that weight loss is a critical step in mitigating cardiovascular and metabolic risks associated with obesity.
Weight loss in morbidly obese patients induces a significant decrease of CRP and IL-6 concentrations in association with an improvement of the IRS.
Why this rating
Longitudinal study with 37 patients, statistically significant results, but small sample size and lack of a non-surgical control group.
Source
Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients
H-G. Kopp et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2003
DOI 10.1161/01.atv.0000073313.16135.21
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