Hormonal
The decrease in insulin resistance is independently associated with the decrease in IL-6 concentrations, while the decrease in BMI is independently associated with the decrease in CRP concentrations.
While weight loss reduces overall inflammation, the specific inflammatory marker that improves most closely tracks with insulin sensitivity (IL-6) versus body mass index (CRP). This suggests that managing insulin resistance may require specific attention to IL-6 pathways, while general weight reduction impacts CRP levels.
Multiple regression analysis revealed that the decrease in insulin resistance remained independently and significantly correlated with the decrease in IL-6 concentrations (P<0.01) and the decrease in body mass index with the decrease in CRP (P<0.05), respectively.
Why this rating
Based on multiple regression analysis within the same study, controlling for confounders.
Source
Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients
H-G. Kopp et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2003
DOI 10.1161/01.atv.0000073313.16135.21
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