Research
Energy balance
Calorie restriction (CR) extends lifespan in many organisms, and this effect is mediated by Sirtuins, although the requirement for Sirtuins varies by species, strain, and CR protocol.
Consider modest calorie restriction or time-restricted eating as a strategy to potentially activate Sirtuin pathways. Focus on nutrient-dense foods. Be aware that individual responses vary, and extreme restriction is unnecessary and potentially harmful.
ModerateQualifiesMEDIUM confidence
it is believed that the beneficial effects of CR on lifespan extension and prevention of age-related diseases is mediated by the induction of Sirtuins
Why this rating
Consistent lifespan extension in CR, but Sirtuin dependency is debated.
Source
Sirtuin signaling in cellular senescence and aging
Shin-Hae Lee et al. · BMB Reports · 2019
DOI 10.5483/bmbrep.2019.52.1.290
narrative_reviewCited 427×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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