Research
Hormonal
Non-coding RNAs (miRNAs, lncRNAs, circRNAs) regulate gene expression in metabolic diseases and serve as diagnostic/prognostic biomarkers and potential therapeutic targets.
Research into non-coding RNAs is leading to new diagnostic tools and potential drugs that can silence or enhance specific genes involved in metabolism, offering hope for treating conditions like obesity and diabetes.
GoodSupportsHIGH confidence
Moreover, ncRNAs are good diagnostic and prognostic biomarkers in various diseases, including metabolic diseases.
Why this rating
Supported by extensive literature cited in the review.
Source
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Yanlin Wu et al. · Signal Transduction and Targeted Therapy · 2023
DOI 10.1038/s41392-023-01333-7
narrative_reviewCited 426×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Epigenetic mechanisms, including DNA methylation, histone modification, and non-coding RNA regulation, play a critical role in the initiation and progression of metabolic diseases such as type 2 diabetes, obesity, and NAFLD.Good
- DNA methylation levels in specific genes (e.g., PGC-1α, FTO, TCF7L2) are altered in patients with Type 2 Diabetes and obesity, serving as potential biomarkers for diagnosis and treatment response.Good
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