Mixed
Epigenetic mechanisms, including DNA methylation, histone modification, and non-coding RNA regulation, play a critical role in the initiation and progression of metabolic diseases such as type 2 diabetes, obesity, and NAFLD.
Your lifestyle choices (diet, exercise, stress) can influence how your genes are expressed through epigenetic mechanisms. This means metabolic health is not fixed by your DNA sequence alone. Understanding these mechanisms opens the door for precision medicine, including biomarkers for early detection and drugs that target epigenetic modifications.
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD)...
Why this rating
This is a review article summarizing extensive clinical and basic science studies, citing numerous specific findings.
Source
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Yanlin Wu et al. · Signal Transduction and Targeted Therapy · 2023
DOI 10.1038/s41392-023-01333-7
More from this paper
- DNA methylation levels in specific genes (e.g., PGC-1α, FTO, TCF7L2) are altered in patients with Type 2 Diabetes and obesity, serving as potential biomarkers for diagnosis and treatment response.Good
- Non-coding RNAs (miRNAs, lncRNAs, circRNAs) regulate gene expression in metabolic diseases and serve as diagnostic/prognostic biomarkers and potential therapeutic targets.Good
Related findings · Mixed
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →