Mixed
Exercise improves mitochondrial function and muscle mass maintenance by activating mitochondrial biogenesis and mitophagy, counteracting catabolic signaling pathways triggered by dysfunctional mitochondria.
To maintain muscle mass, especially as you age or if you have chronic conditions, regular exercise is essential. It works by cleaning out damaged mitochondria (mitophagy) and building new, efficient ones (biogenesis). This process prevents the cellular signals that cause muscle wasting. Focus on consistent physical activity rather than complex supplements.
Exercise, on the other hand, improves mitochondrial function by activating mitochondrial biogenesis and mitophagy, possibly playing an important part in the beneficial effects of physical activity in several diseases.
Why this rating
This is a review paper citing multiple primary studies and established pathways; high quality evidence but not a single primary trial.
Source
Mitochondrial Quality Control and Muscle Mass Maintenance
Vanina Romanello et al. · Frontiers in Physiology · 2016
DOI 10.3389/fphys.2015.00422
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