Research
Micronutrients & recovery
Supplements including Vitamin D, Resveratrol, Alpha-lipoic acid, Omega-3, Berberine, Folic acid, Myoinositol (MI), and D-chiro-inositol (DCI) are effective adjunctive therapies for PCOS, improving insulin sensitivity, lipid profiles, and ovulation.
Consider adding specific supplements to your regimen: Vitamin D (especially in cold seasons), Resveratrol, Alpha-lipoic acid, Omega-3, Berberine, Folic acid, Myoinositol, and D-chiro-inositol. These may improve insulin sensitivity and lipid profiles.
ModerateSupportsMEDIUM confidence
Apart from medications with USFDA approval, plenty of supplementation products has been shown to be effective in some women with PCOS. These products include vitamin D supplements, resveratrol, α-lipoic acid, omega-3, berberine, folic acid, myoinositol (MI), and d-chiro-inositol (DCI).
Why this rating
The paper cites various studies but notes they are part of a broader review.
Source
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
Hosna Mohammad Sadeghi et al. · International Journal of Molecular Sciences · 2022
DOI 10.3390/ijms23020583
narrative_reviewCited 425×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Lifestyle modifications, specifically weight loss of 5-10% combined with regular exercise (150 min moderate or 75 min vigorous per week) and a diet rich in fiber/low in saturated fats and high-glycemic carbohydrates, are the preferred first-line therapy for managing Polycystic Ovary Syndrome (PCOS) symptoms and restoring ovulation.Good
- Drug repurposing using agents such as metformin (implied by insulin sensitizers), pioglitazone, empagliflozin, sitagliptin, liraglutide, statins (simvastatin, atorvastatin), and N-acetyl cysteine shows supporting data for managing PCOS by targeting insulin resistance, hyperandrogenism, and oxidative stress.Moderate
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