Research
Mixed
Innate and adaptive immune cells (Kupffer cells, monocytes, neutrophils, T cells) are central drivers of NASH inflammation and fibrosis, with specific pathways like NLRP3 inflammasome activation and CCL2/CCR2 monocyte recruitment being critical for disease progression.
NASH involves active inflammation driven by immune cells, not just fat accumulation. Targeting immune pathways (like CCL2/CCR2 or NLRP3) is a key area of research for treating NASH.
GoodSupportsHIGH confidence
Innate and adaptive immune mechanisms involving macrophages, dendritic cells, and lymphocytes are central drivers of inflammation that recognize damage- and pathogen-associated molecular patterns and contribute to the progression of the inflammatory cascade... The recruitment of bone marrow-derived monocytes has been shown to be a critical event in the progression of NASH.
Why this rating
Review of human biopsies, animal models, and genetic studies.
Source
Pathogenesis of Nonalcoholic Steatohepatitis: An Overview
Gopanandan Parthasarathy et al. · Hepatology Communications · 2020
DOI 10.1002/hep4.1479
narrative_reviewCited 421×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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