Research
Hormonal
Maintaining serum 25(OH)D concentrations above 30 ng/mL (50 nmol/L) reduces oxidative stress, inflammation, and mitochondrial dysfunction, thereby slowing aging and reducing all-cause mortality.
Aim for a serum 25(OH)D level of at least 30 ng/mL. This can often be achieved through sensible sun exposure or supplementation (e.g., 1000-4000 IU/day for most adults). This supports mitochondrial health and reduces oxidative stress, which are key drivers of aging.
ModerateSupportsMEDIUM confidence
Vitamin D adequacy leads to less oxidative stress and improves mitochondrial and endocrine functions, reducing the risks of disorders, such as autoimmunity, infections, metabolic derangements, and impairment of DNA repair; all of this aids a healthy, graceful aging process.
Why this rating
The paper is a review citing observational and mechanistic studies, explicitly noting a lack of large-scale RCTs with hard endpoints.
Source
Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging
Sunil J. Wimalawansa · Biology · 2019
DOI 10.3390/biology8020030
narrative_reviewCited 419×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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