Research
Hormonal
Vitamin D deficiency impairs mitochondrial respiration, increases reactive oxygen species (ROS), and accelerates cellular aging and apoptosis.
If you are vitamin D deficient, correcting this status may help protect mitochondrial function and reduce oxidative stress, which are linked to aging.
ModerateRefutesMEDIUM confidence
Chronic vitamin D deficiency reduces the capacity of mitochondrial respiration through modulating nuclear mRNA... downregulates the expression of complex I of the electron transport chain and thus reduces the formation of adenosine triphosphate (ATP)... increases the formation of ROS and oxidative stress...
Why this rating
Based on mechanistic reviews and animal studies cited in the paper.
Source
Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging
Sunil J. Wimalawansa · Biology · 2019
DOI 10.3390/biology8020030
narrative_reviewCited 419×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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