Research
Hormonal
Inflammaging, characterized by chronic low-grade elevation of proinflammatory cytokines (IL-6, TNF, IL-1), drives age-related functional decline, sarcopenia, and frailty through tissue damage and immune remodelling.
Chronic, low-grade inflammation is a primary driver of muscle loss and frailty in older adults. Managing body composition (reducing visceral fat) and stress (to modulate cortisol/DHEAS ratios) are key strategies to mitigate this inflammatory burden and preserve functional ability.
GoodSupportsHIGH confidence
Inflammaging denotes an upregulation of the inflammatory response that occurs with age, resulting in a low-grade chronic systemic proinflammatory state... Inflammaging is also implicated in the progression of osteoporosis and dementia; both strongly implicated in the frailty syndrome.
Why this rating
Based on a comprehensive review of multiple observational and mechanistic studies, though lacking direct interventional trials for the core mechanism.
Source
Understanding how we age: insights into inflammaging
D. Baylis et al. · Longevity & Healthspan · 2013
DOI 10.1186/2046-2395-2-8
narrative_reviewCited 413×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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