Research
Hormonal
The cortisol-to-DHEAS ratio is a more accurate predictor of frailty and mortality than cortisol or DHEAS levels alone, as DHEAS antagonizes cortisol's catabolic and immunosuppressive effects.
Focus on maintaining a healthy cortisol-to-DHEAS balance by managing stress and body composition. While DHEA supplementation exists, its benefits are inconsistent, and lifestyle interventions that naturally support hormonal balance are more reliable for preventing frailty.
GoodSupportsHIGH confidence
Therefore, when considering the effects of the HPA axis on inflammaging, the ratio of cortisol to DHEAS (Figure 3) may more accurately reflect the HPA axis than either cortisol or DHEAS alone.
Why this rating
Supported by longitudinal observational studies and in-vitro data, but direct interventional evidence for ratio manipulation is limited.
Source
Understanding how we age: insights into inflammaging
D. Baylis et al. · Longevity & Healthspan · 2013
DOI 10.1186/2046-2395-2-8
narrative_reviewCited 413×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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