Research
Energy balance
Obese individuals exhibit increased fasting gastric volume and delayed satiation, allowing them to consume significantly more calories before reaching maximum satiation compared to normal-weight individuals.
If you struggle with obesity, your stomach may physiologically require more food to signal fullness (satiation) than a normal-weight person. This is not a character flaw but a physiological difference in fasting gastric volume and satiety signaling. Understanding this can help in managing expectations and potentially targeting therapies that enhance satiety signals.
GoodSupportsHIGH confidence
Increased body mass and fasting gastric volumes are independently associated with delayed satiation under standard laboratory conditions of food ingestion... an increase of 50 mL in the fasting gastric volume was associated with 114±32 kcal (479±134 kJ) more ingested at maximum satiation.
Why this rating
Based on large-scale studies (>500 patients) using barostat and imaging techniques.
Source
The stomach in health and disease
Richard H. Hunt et al. · Gut · 2015
DOI 10.1136/gutjnl-2014-307595
narrative_reviewCited 412×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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