Hormonal
2-deoxy-D-glucose (2DG) acts as a calorie restriction mimetic by inhibiting glycolysis, thereby reducing plasma insulin and body temperature without significantly reducing food intake or body weight in rats.
This paper discusses 2-deoxyglucose (2DG) as a potential anti-aging compound in rats that lowers insulin and body temperature without dieting. However, it also notes that high doses are toxic and cause heart failure in rats. There is no human protocol provided, and the compound is not currently a standard human supplement due to safety concerns and lack of long-term human data.
The major findings from this initial study were that a 2DG diet could affect two major biomarkers of CR, specifically to reduce insulin and body temperature, with little or no effects on food intake and body weight.
Why this rating
Based on rodent studies (Fischer-344 rats) showing physiological biomarkers, but lacking long-term lifespan data in the text.
Source
Calorie restriction mimetics: an emerging research field
Donald K. Ingram et al. · Aging Cell · 2006
DOI 10.1111/j.1474-9726.2006.00202.x
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