Research
Hormonal
Resveratrol, a sirtuin-activating compound (STAC), increases lifespan in nematodes and fruit flies in a Sir2-dependent manner, mimicking calorie restriction.
Resveratrol activates sirtuins and extends lifespan in worms and flies, mimicking calorie restriction. However, the paper explicitly states that these pro-longevity effects have not yet been confirmed in mammals, so it should not be relied upon as a proven human anti-aging intervention based on this text alone.
ModerateSupportsMEDIUM confidence
This polyphenol has been shown to increase lifespan in nematodes and fruit flies in a Sir2-dependent manner that appeared to mimic CR (Wood et al., 2004).
Why this rating
Based on invertebrate studies; mammalian confirmation is explicitly stated as lacking in the text.
Source
Calorie restriction mimetics: an emerging research field
Donald K. Ingram et al. · Aging Cell · 2006
DOI 10.1111/j.1474-9726.2006.00202.x
narrative_reviewCited 412×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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