Research
Energy balance
PPARgamma activation promotes the browning of white adipose tissue (beige adipocytes) and enhances brown adipose tissue (BAT) function, leading to increased energy expenditure and thermogenesis.
Activating brown fat through cold exposure or potentially PPARgamma-activating strategies can boost calorie burning via thermogenesis.
GoodSupportsHIGH confidence
An increase in non-shivering thermogenesis was observed in mice treated with TZDs... activation of PPARg in brown adipocytes leads to increase in adipogenesis and increase in lipid metabolism.
Why this rating
Supported by mouse studies and human imaging (PET/CT) cited in the review.
Source
PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action
Miguel Hernández-Quiles et al. · Frontiers in Endocrinology · 2021
DOI 10.3389/fendo.2021.624112
narrative_reviewCited 411×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- PPARgamma mutations (loss-of-function) cause familial partial lipodystrophy type 3 (FPLD3), characterized by lack of subcutaneous fat in extremities and metabolic complications like type 2 diabetes.Strong
- PPARgamma activation via thiazolidinediones (TZDs) like rosiglitazone and pioglitazone induces a metabolically beneficial shift in lipid repartitioning from visceral and ectopic storage (liver, muscle) to subcutaneous adipose tissue.Good
- PPARgamma activation in immune cells (macrophages, dendritic cells, T cells) suppresses pro-inflammatory signaling pathways (NF-kB, AP-1) via transrepression, reducing the production of inflammatory cytokines like TNF-alpha, IL-1beta, and IL-6.Good
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