Research
Micronutrients & recovery
Vitamin E (800 IU/day of natural RRR-alpha-tocopherol) improves NASH histology in non-diabetic patients, but carries potential risks including increased mortality and hemorrhagic stroke in broader populations.
Natural Vitamin E (800 IU daily for 96 weeks) significantly improves liver inflammation in non-diabetics. However, it is not risk-free; high doses have been linked to increased mortality and stroke risk in other studies. It should be used under medical supervision, particularly in non-diabetics without cirrhosis.
GoodQualifiesHIGH confidence
In the PIVENS phase III RDBPCT, vitamin E at a dose of 800 IU/day for 96 weeks was superior to placebo, achieving histological response in 43% of subjects (compared with 19% of placebo, p=0.001) and resolution of NASH in 36%. ... A large meta-analysis of 135 000 patients from 19 studies that used vitamin E demonstrated an increase in all-cause mortality, Treatment with vitamin E was associated with an increased risk of haemorrhagic stroke, attributed to an anti-platelet effect of high-dose treatment.
Why this rating
Based on the PIVENS phase III RDBPCT, a large and robust trial.
Source
Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
Yaron Rotman et al. · Gut · 2016
narrative_reviewCited 403×
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