Research
Micronutrients & recovery
Vitamin E (800 IU/day of natural RRR-alpha-tocopherol) improves NASH histology in non-diabetic patients, but carries potential risks including increased mortality and hemorrhagic stroke in broader populations.
Natural Vitamin E (800 IU daily for 96 weeks) significantly improves liver inflammation in non-diabetics. However, it is not risk-free; high doses have been linked to increased mortality and stroke risk in other studies. It should be used under medical supervision, particularly in non-diabetics without cirrhosis.
GoodQualifiesHIGH confidence
In the PIVENS phase III RDBPCT, vitamin E at a dose of 800 IU/day for 96 weeks was superior to placebo, achieving histological response in 43% of subjects (compared with 19% of placebo, p=0.001) and resolution of NASH in 36%. ... A large meta-analysis of 135 000 patients from 19 studies that used vitamin E demonstrated an increase in all-cause mortality, Treatment with vitamin E was associated with an increased risk of haemorrhagic stroke, attributed to an anti-platelet effect of high-dose treatment.
Why this rating
Based on the PIVENS phase III RDBPCT, a large and robust trial.
Source
Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
Yaron Rotman et al. · Gut · 2016
DOI 10.1136/gutjnl-2016-312431
narrative_reviewCited 403×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Liraglutide (1.8 mg/day) induces histological resolution of NASH without worsening fibrosis in non-diabetic and diabetic patients, primarily by improving hepatic insulin sensitivity and reducing de novo lipogenesis, independent of weight loss magnitude.Good
- Pioglitazone (30 mg/day) improves NASH histology in non-diabetic patients, but its clinical use is limited by side effects including weight gain and potential cardiovascular risks.Good
- Obeticholic acid (25 mg/day) significantly improves NASH histology and fibrosis in non-cirrhotic patients, but is associated with pruritus and adverse lipid changes.Good
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →