Research
Mixed
The molecular signaling responses to acute resistance and endurance exercise are often similar in untrained or recreationally active individuals, suggesting the interference effect may be less pronounced or mechanistically distinct in this population.
If you are new to exercise, you likely won't experience the 'interference effect' as strongly as an athlete. You can probably combine cardio and weights without worrying too much about blunting gains, as your body is still adapting to both stimuli.
ModerateQualifiesMEDIUM confidence
Given divergent exercise induces similar signalling and gene expression profiles in skeletal muscle of untrained or recreationally active individuals, what is currently unclear is how the specificity of the molecular response is modified by prior training history.
Why this rating
Based on acute studies and hypotheses regarding training history.
Source
Concurrent exercise training: do opposites distract?
Vernon G. Coffey et al. · The Journal of Physiology · 2016
DOI 10.1113/jp272270
narrative_reviewCited 338×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Concurrent endurance and resistance training attenuates gains in muscle hypertrophy and strength compared to resistance training alone, a phenomenon termed the 'interference effect'.Good
- Endurance training does not compromise gains in aerobic capacity when performed concurrently with resistance training.Good
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