Research
Micronutrients & recovery
Oral administration of 600 mg/day of alpha-lipoic acid (ALA) significantly improves symptoms of diabetic sensorimotor polyneuropathy and prevents disease progression in patients with mild-to-moderate diabetic neuropathy.
If you have diabetic neuropathy, ask your doctor about 600 mg of Alpha-Lipoic Acid daily. Clinical studies show it can reduce pain and numbness and may prevent nerve damage from getting worse over time, especially if you have Type 1 diabetes or are a smoker. It is generally well-tolerated.
GoodSupportsHIGH confidence
The treatment of diabetic patients with mild-to-moderate DSPN with 600 mg of ALA per day orally increased the neuropathy impairment score of lower limbs (NIS-LL) after four years... ALA might have the potential to prevent the neuropathic impairments progression with regular long-term administration.
Why this rating
Based on multiple randomized, double-blind, placebo-controlled clinical trials cited (Ziegler et al., Agathos et al.).
Source
Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
Bahare Salehi et al. · Biomolecules · 2019
DOI 10.3390/biom9080356
narrative_reviewCited 398×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The R-enantiomer of alpha-lipoic acid has superior pharmacokinetic parameters, including higher bioavailability and plasma concentrations, compared to the S-enantiomer or racemic mixtures.Good
- Alpha-lipoic acid bioavailability is significantly reduced when taken with food, and should be administered on an empty stomach to maximize absorption.Moderate
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