Research
Mixed
EPA and DHA modify cell membrane structure and function, leading to altered lipid mediator production (eicosanoids, resolvins, protectins) and gene expression, which underlies their anti-inflammatory and immune-modulating effects.
Consuming EPA and DHA changes how your cells work. They become more fluid, produce different signaling molecules (some anti-inflammatory), and change which genes are turned on or off. This is how fish oil exerts its health benefits.
StrongSupportsVERY_HIGH confidence
Increased content of EPA and DHA modifies the structure of cell membranes and the function of membrane proteins. EPA and DHA modulate the production of lipid mediators and through effects on cell signalling can alter the patterns of gene expression.
Why this rating
Well-established biochemical pathways described in detail.
Source
Very long-chain<i>n</i>-3 fatty acids and human health: fact, fiction and the future
Philip C. Calder · Proceedings of The Nutrition Society · 2017
narrative_reviewCited 395×
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