Mixed
Gut dysbiosis, characterized by a decrease in beneficial commensals (e.g., Akkermansia muciniphila) and short-chain fatty acids (SCFAs) and an increase in pro-inflammatory microbes, triggers systemic inflammation (inflammaging) and gut leakiness, which are primary drivers of aging-associated morbidities and premature death in the elderly.
Focus on maintaining a diverse and healthy gut microbiome through diet and lifestyle choices, as this appears to be a key factor in healthy aging and longevity. This includes consuming fiber-rich foods to support beneficial bacteria and SCFA production, and potentially avoiding unnecessary antibiotics. While individual results may vary, the evidence suggests that gut health is a critical lever for mitigating age-related decline.
Here, we present the authors’ thoughts that underscore dysbiosis as a primary cause of aging-associated morbidities, and thus, premature death of elderly people. We provide evidence that the dysbiosis triggers a chain of pathological and inflammatory events. Examples include alteration of levels of microbiota-affected metabolites, impaired function and integrity of the gastrointestinal tract, and increased gut leakiness. All of these enhance systemic inflammation, which when associated with aging is termed inflammaging, and result in consequent aging-associated pathologies.
Why this rating
The paper is a review summarizing observational studies, animal models, and some mechanistic insights, but notes 'contradictory reports' and 'high degree of variability' in human microbiota.
Source
Gut microbiota as the key controllers of “healthy” aging of elderly people
Emeline Ragonnaud et al. · Immunity & Ageing · 2021
DOI 10.1186/s12979-020-00213-w
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