Research
Hormonal
Weight loss interventions restore the normal secretion pattern of adipokines, reducing inflammatory markers and improving metabolic profiles.
Losing weight through diet is the most effective way to fix the hormonal imbalance caused by obesity. As you lose weight, your fat tissue stops pumping out inflammatory signals, which improves your insulin sensitivity and reduces cardiovascular risk.
GoodSupportsHIGH confidence
The treatment of choice is weight loss by dietary measures, as this approach has repeatedly been shown to be associated with restoration of normal secretion of the adipokines under investigation.
Why this rating
Based on a review of multiple studies showing consistent restoration of secretion patterns.
Source
Secretory factors from human adipose tissue and their functional role
Hans Hauner · Proceedings of The Nutrition Society · 2005
DOI 10.1079/pns2005428
narrative_reviewCited 389×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity induces a pro-inflammatory state in adipose tissue characterized by elevated secretion of cytokines (TNF-α, IL-6, IL-8) and PAI-1, which contributes to insulin resistance and cardiovascular risk.Good
- Pharmacological agents such as thiazolidinediones, metformin, and statins can directly modify adipose tissue secretion to reduce inflammation and improve metabolic markers.Moderate
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