Research
Hormonal
Pharmacological agents such as thiazolidinediones, metformin, and statins can directly modify adipose tissue secretion to reduce inflammation and improve metabolic markers.
Certain diabetes and cholesterol medications can help your fat tissue function better by reducing harmful inflammatory signals. However, weight loss remains the primary treatment.
ModerateSupportsMEDIUM confidence
In addition to dietary treatment there is also growing evidence that frequently-used drugs with anti-inflammatory activity, such as thiazolidinediones, metformin and angiotensin II type 1 receptor antagonists, may directly influence the secretory function of human adipose tissue.
Why this rating
The paper cites studies but notes 'little is known' about the extent of these effects compared to weight loss.
Source
Secretory factors from human adipose tissue and their functional role
Hans Hauner · Proceedings of The Nutrition Society · 2005
DOI 10.1079/pns2005428
narrative_reviewCited 389×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity induces a pro-inflammatory state in adipose tissue characterized by elevated secretion of cytokines (TNF-α, IL-6, IL-8) and PAI-1, which contributes to insulin resistance and cardiovascular risk.Good
- Weight loss interventions restore the normal secretion pattern of adipokines, reducing inflammatory markers and improving metabolic profiles.Good
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