Research
Macro partitioning
High dietary fat intake is associated with an increased incidence of certain cancers, particularly breast cancer, as evidenced by concordant epidemiological and laboratory animal studies.
While the specific mechanisms are still being researched, current evidence suggests that a diet very high in fat may increase the risk of certain cancers, such as breast cancer. It is advisable to maintain a balanced intake of fats rather than consuming excessive amounts, and to prioritize whole food sources of fat.
ModerateSupportsMEDIUM confidence
epidemiologists observed that the high incidence of breast cancer and certain other cancers is associated with a diet high in fat or its components, and laboratory investigators found that mammary cancers in certain species were similarly modified by changes in the amounts and types of dietary fat.
Why this rating
The paper cites concordant epidemiological and animal data but notes that specific active constituents and exact mechanisms are not yet fully defined.
Source
Diet and Cancer
Walter C. Willett · The Oncologist · 2000
DOI 10.1634/theoncologist.5-5-393
narrative_reviewCited 243×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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