Micronutrients & recovery
Supplementation with NAD+ precursors (NMN or NR) mitigates age-associated functional decline by restoring NAD+ levels, thereby activating sirtuins (SIRT1, SIRT3, SIRT6) and improving mitochondrial and systemic metabolic health.
As you age, your body's natural production of NAD+ declines, which reduces the activity of sirtuins—enzymes critical for mitochondrial health and metabolic regulation. Supplementing with NAD+ precursors like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) can help restore NAD+ levels. This restoration supports sirtuin activity, potentially improving mitochondrial function and metabolic health, thereby mitigating some age-related functional decline. Consult a healthcare provider for appropriate dosing.
To mitigate these age-associated problems, supplementation of key NAD+ intermediates is currently drawing significant attention... supplementing key NAD+ intermediates, such as NMN and NR, is expected to mitigate age-associated functional decline and ameliorate a variety of age-associated pathophysiologies.
Why this rating
The paper is a review article summarizing preclinical and some clinical evidence; it cites specific studies but does not present new primary clinical trial data itself.
Source
It takes two to tango: NAD+ and sirtuins in aging/longevity control
Shin‐ichiro Imai et al. · npj Aging and Mechanisms of Disease · 2016
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