Mixed
Dietary polyphenols (catechins, anthocyanins, resveratrol, curcumin) modulate energy metabolism and adiposity through mechanisms including AMPK activation, inhibition of adipogenesis, and suppression of angiogenesis, though human clinical efficacy remains inconsistent and high-dose supplementation carries toxicity risks.
Incorporate polyphenol-rich foods (green tea, berries, turmeric, red grapes) into a balanced diet as part of a healthy lifestyle. Do not rely on high-dose supplements for weight loss, as they are ineffective in many human studies and carry risks of liver toxicity. Focus on whole foods rather than extracts to maximize benefits while minimizing risks.
Polyphenols are a class of naturally-occurring phytochemicals, of which some such as catechins, anthocynines, resveratrol and curcumin have been shown to modulate physiological and molecular pathways that are involved in energy metabolism, adiposity, and obesity.
Why this rating
The paper is a review of preclinical (cell/animal) and limited human studies; human data is described as inconsistent and lacking long-term safety data.
Source
Dietary Polyphenols and Obesity
Mohsen Meydani et al. · Nutrients · 2010
DOI 10.3390/nu2070737
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