Mixed
Increased DNA methylation age (epigenetic age acceleration) is associated with an 8-15% increased risk of all-cause mortality for every 5-year increase in epigenetic age.
This paper establishes that your biological age, measured by DNA methylation patterns, is a stronger predictor of death than your calendar age. While this specific paper does not offer an intervention, it implies that factors accelerating biological age (like smoking, obesity, or stress, which are linked to higher DNAmAge) are modifiable risk factors for mortality. Focus on lifestyle factors known to reduce inflammation and oxidative stress, as these are correlated with slower epigenetic aging.
Meta-analyses indicated that each 5-year increase in DNA methylation age was associated an 8 to 15% increased risk of mortality.
Why this rating
It is a systematic review and meta-analysis of 23 studies, but the authors note 'inconsistent' evidence for disease and 'positive publication bias' for mortality.
Source
The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Peter Fransquet et al. · Clinical Epigenetics · 2019
DOI 10.1186/s13148-019-0656-7
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