Research
Mixed
Sibutramine improves lipid profiles (HDL, triglycerides) but increases blood pressure and heart rate, while rimonabant improves lipid profiles and glycaemic control but increases the risk of mood disorders.
Sibutramine and rimonabant can improve your cholesterol and blood sugar, but they come with specific risks: sibutramine raises blood pressure and heart rate, while rimonabant increases the risk of mood disorders. Your doctor will screen you to ensure these risks are manageable.
GoodQualifiesHIGH confidence
Sibutramine improved HDL and triglyceride levels but raised blood pressure and pulse rate. Rimonabant improved HDL-cholesterol, triglyceride and blood pressure levels and glycaemic control in patients with diabetes but increased the risk of mood disorders.
Why this rating
Based on subgroup analyses and adverse event reporting in RCTs.
Source
Long-term pharmacotherapy for obesity and overweight
Raj Padwal et al. · Cochrane Database of Systematic Reviews · 2003
DOI 10.1002/14651858.cd004094.pub2
Meta-analysis · 30 studiesCited 381×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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Related findings · Mixed
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