Research
Mixed
Chronic low-grade inflammation (inflammaging) acts as a bidirectional driver that exacerbates all other hallmarks of aging, creating a vicious cycle that accelerates biological aging and age-related diseases.
Chronic, low-grade inflammation is a central accelerator of aging. While not an intervention itself, understanding 'inflammaging' highlights the importance of lifestyle factors (diet, exercise) that modulate immune response and reduce this persistent inflammatory state, thereby potentially slowing the progression of age-related diseases.
StrongSupportsHIGH confidence
The crosstalk between chronic inflammation and other hallmarks of aging results in a vicious cycle that exacerbates the decline in cellular functions and promotes aging.
Why this rating
This is a comprehensive review of established mechanisms in geroscience, citing numerous primary studies.
Source
Chronic inflammation and the hallmarks of aging
Jordan J. Baechle et al. · Molecular Metabolism · 2023
narrative_reviewCited 379×
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