Macro partitioning
Higher intake of trans fatty acids (TFA) is associated with a significantly increased risk of cardiovascular disease (CVD) in a dose-response manner.
Avoid trans fatty acids. This meta-analysis confirms that higher TFA intake increases CVD risk, with a 16% increase in risk for every 2% of daily energy intake from TFA. Unlike total fat, saturated fat, or unsaturated fats, TFA shows a clear harmful dose-response relationship.
higher dietary trans fatty acids (TFA) intake was associated with increased risk of CVDs [RR:1.14(1.08–1.21)]... the risk of CVDs increased 16% [1.16 (1.07–1.25), Plinearity = 0.033] for an increment of 2% energy/day of TFA intake.
Why this rating
High-quality meta-analysis of prospective cohort studies with large sample sizes, though observational design limits causal inference compared to RCTs.
Source
Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies
Yongjian Zhu et al. · Lipids in Health and Disease · 2019
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