Mixed
A composite panel of seven circulating senescence-associated secretory phenotype (SASP) proteins (GDF15, FAS, OPN, TNFR1, ACTIVIN A, CCL3, and IL-15) serves as a superior biomarker for predicting adverse postoperative outcomes and biological age compared to chronological age or single-protein markers.
This research suggests that measuring a specific set of 7 proteins in the blood (GDF15, FAS, OPN, TNFR1, ACTIVIN A, CCL3, and IL-15) can provide a more accurate assessment of biological age and surgical risk than chronological age. For older adults, this panel may help identify those at higher risk for complications after surgery, potentially guiding pre-operative care and post-operative monitoring.
A panel of 7 SASP factors composed of growth differentiation factor 15 (GDF15), TNF receptor superfamily member 6 (FAS), osteopontin (OPN), TNF receptor 1 (TNFR1), ACTIVIN A, chemokine (C-C motif) ligand 3 (CCL3), and IL-15 predicted adverse events markedly better than a single SASP protein or age.
Why this rating
The study uses multiple cohorts (biobank, aortic stenosis, ovarian cancer) and robust statistical modeling (GBM, ROC AUC), but is observational and limited to specific surgical populations.
Source
The senescence-associated secretome as an indicator of age and medical risk
Marissa Schafer et al. · JCI Insight · 2020
DOI 10.1172/jci.insight.133668
Related findings · Mixed
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