Research
Macro partitioning
Partial replacement of saturated fat with polyunsaturated fat (PUFA) decreases the risk of cardiovascular disease (CVD), particularly in men.
To lower your risk of heart disease, replace saturated fats (butter, fatty meats) with polyunsaturated fats (vegetable oils, nuts, fish). This change is strongly linked to a lower risk of cardiovascular events, especially for men.
StrongSupportsVERY_HIGH confidence
Furthermore, there was convincing evidence that partial replacement of SFA with PUFA decreases the risk of CVD, especially in men.
Why this rating
Graded as 'convincing' by the systematic review committee.
Source
Effect of the amount and type of dietary fat on cardiometabolic risk factors and risk of developing type 2 diabetes, cardiovascular diseases, and cancer: a systematic review
Ursula Schwab et al. · Food & Nutrition Research · 2014
DOI 10.3402/fnr.v58.25145
systematic_reviewCited 375×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Partial replacement of saturated fatty acids (SFA) with polyunsaturated (PUFA) or monounsaturated fatty acids (MUFA) significantly lowers fasting total and LDL cholesterol concentrations.Strong
- Replacing saturated fat with monounsaturated fat (MUFA) or polyunsaturated fat (PUFA) improves insulin sensitivity and lowers fasting insulin concentrations compared to saturated fat diets.Good
- Fish oil (n-3 LCPUFA) supplementation lowers serum triglyceride (TAG) concentrations compared to monounsaturated fat (MUFA) sources.Good
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