Mixed
A metabolic biomarker score derived from 14 circulating metabolites (including lipids, amino acids, and inflammatory markers) provides significantly better prediction of 5- and 10-year all-cause mortality than conventional clinical risk factors across all adult ages.
Standard blood tests (cholesterol, blood pressure) are not enough to accurately predict your risk of dying in the next 5-10 years, especially as you age. A specialized metabolic blood test (NMR metabolomics) that looks at 14 specific markers (lipids, amino acids, inflammation) provides a much more accurate risk score. This tool is currently best used by clinicians to make high-stakes decisions, such as determining if an elderly patient is too frail for surgery, rather than for self-management.
the prediction accuracy of 5- and 10-year mortality based on a model containing the identified biomarkers and sex (C-statistic = 0.837 and 0.830, respectively) is better than that of a model containing conventional risk factors for mortality (C-statistic = 0.772 and 0.790, respectively).
Why this rating
Large-scale meta-analysis of 44,168 individuals with robust statistical validation (C-statistic, IDI) and reproducibility across cohorts.
Source
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
Joris Deelen et al. · Nature Communications · 2019
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