Research
Hormonal
High-fat diets increase the absorption of lipopolysaccharides (LPS) from Gram-negative bacteria, leading to metabolic endotoxemia, chronic inflammation, and increased adiposity.
High-fat diets can damage your gut barrier, allowing bacterial toxins (LPS) into your bloodstream. This triggers inflammation that promotes fat storage and insulin resistance. Reducing excessive fat intake and supporting gut barrier integrity may help mitigate this inflammatory response.
ModerateSupportsMEDIUM confidence
High fat diet increases the absorption of LPS, which, in turn, has been found to be associated with metabolic endotoxemia and to induce inflammation resulting in obesity.
Why this rating
Based on a review of multiple studies including animal models and human observations.
Source
New-found link between microbiota and obesity
Chandra Kanti Chakraborti · World Journal of Gastrointestinal Pathophysiology · 2015
DOI 10.4291/wjgp.v6.i4.110
narrative_reviewCited 372×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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