Mixed
High baseline total cholesterol (TC) is significantly associated with an increased risk of myocardial infarction (MI) in men, whereas associations for LDL-C, triglycerides, and total CVD events disappear after adjusting for confounders like diet and BMI.
For middle-aged men, monitoring Total Cholesterol (TC) is crucial for predicting heart attack risk, potentially more so than LDL-C alone when other health factors are considered. Ensure your TC is managed through a balanced diet and lifestyle, as high levels are strongly linked to myocardial infarction in this demographic.
However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12–6.57; P-value< 0.05).
Why this rating
Large prospective cohort (n=8698), long follow-up (6 years), and rigorous multivariable adjustment, though observational design prevents causal inference.
Source
Dyslipidemia and cardiovascular disease risk among the MASHAD study population
Mahshad Hedayatnia et al. · Lipids in Health and Disease · 2020
DOI 10.1186/s12944-020-01204-y
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