Energy balance
Activation of PPARβ/δ by the agonist GW501516 in skeletal muscle cells induces the expression of genes involved in lipid catabolism, cholesterol efflux, and energy uncoupling, thereby increasing fatty acid oxidation and energy expenditure.
This research identifies PPARβ/δ as a key regulator in muscle that shifts energy usage toward burning fatty acids and generating heat (uncoupling). While GW501516 itself is a research chemical and not a consumer supplement, the findings suggest that strategies or compounds targeting this pathway could theoretically enhance fat oxidation and energy expenditure in skeletal muscle.
Activation of PPARβ/δ by GW501516 in skeletal muscle cells induces the expression of genes involved in preferential lipid utilization, β-oxidation, cholesterol efflux, and energy uncoupling.
Why this rating
High-quality in vitro mechanistic study with validation via Northern blot and qPCR, though limited to cell culture (C2C12) and not human clinical trials.
Source
The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells
Uwe Dressel et al. · Molecular Endocrinology · 2003
DOI 10.1210/me.2003-0151
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