Research
Energy balance
Inhibition of brown adipose tissue development by Wnt10b leads to cold intolerance and reduced oxygen consumption, indicating a loss of adaptive thermogenesis.
Brown fat plays a crucial role in thermoregulation and energy expenditure. While this study uses a genetic model to block brown fat, it underscores the importance of maintaining metabolic flexibility. For humans, exposure to mild cold and regular exercise can help maintain brown fat activity, potentially aiding in energy balance and metabolic health.
GoodSupportsHIGH confidence
FABP4-Wnt10b mice are unable to maintain a core body temperature when placed in a cold environment... oxygen consumption is decreased.
Why this rating
Robust in vivo data showing physiological consequences of brown fat loss.
Source
Wnt10b Inhibits Development of White and Brown Adipose Tissues
Kenneth Longo et al. · Journal of Biological Chemistry · 2004
DOI 10.1074/jbc.m402937200
mechanism_onlyCited 370×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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