Hormonal
Weight loss and lifestyle modifications (diet, exercise, sleep) are the most effective management strategies for PCOS, as they improve insulin sensitivity, reduce hyperandrogenism, and restore reproductive function.
Focus on sustainable lifestyle changes rather than quick fixes. Aim for a modest 5% weight loss if overweight, as this significantly improves PCOS symptoms. Engage in 30-60 minutes of moderate physical activity daily; avoid excessive exercise which may worsen anovulation. Prioritize sleep sufficiency (7-8 hours) as it is a prerequisite for successful weight loss and metabolic health.
Given the central role of the dysfunctional insulin signalling in the pathogenesis of PCOS, it is perhaps not surprising that the most effective management strategies for this condition include attempts to improve function of this pathway, including most notably through effective and sustained weight loss.
Why this rating
Based on a comprehensive review of literature and meta-analyses cited in the text, though specific primary trial data is not detailed.
Source
Obesity and polycystic ovary syndrome
Thomas M. Barber et al. · Clinical Endocrinology · 2021
DOI 10.1111/cen.14421
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