Hormonal
Malabsorptive bariatric surgery (BPD) reverses type 2 diabetes within 1-4 weeks by normalizing peripheral insulin sensitivity and enhancing beta-cell glucose sensitivity, independent of significant weight loss.
For morbidly obese individuals with type 2 diabetes, malabsorptive bariatric surgery (like BPD) can reverse the disease within weeks, largely by improving how the body uses insulin and how the pancreas responds to glucose, rather than just through weight loss. This suggests that surgical alteration of gut anatomy has a direct hormonal impact on diabetes.
BPD determines a prompt reversibility of type 2 diabetes by normalizing peripheral insulin sensitivity and enhancing beta-cell sensitivity to glucose, these changes occurring very early after the operation.
Why this rating
Small sample size (n=10) and short duration (4 weeks), but uses gold-standard measurement techniques (clamp).
Source
Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery
Caterina Guidone et al. · Diabetes · 2006
DOI 10.2337/db06-0068
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