Research
Hormonal
BPD increases fasting and stimulated GLP-1 levels while decreasing GIP levels, contributing to improved beta-cell sensitivity and insulin sensitivity.
BPD works partly by changing which parts of the intestine see food. By sending undigested food to the ileum, it boosts GLP-1 (a hormone that helps insulin work), and by bypassing the duodenum/jejunum, it reduces GIP (which may contribute to insulin resistance).
GoodSupportsHIGH confidence
BPD operation may affect the enteroinsular axis function by diverting nutrients away from the proximal gastrointestinal tract and by delivering incompletely digested nutrients to the ileum... enhances the secretion of GLP-1 in the transposed ileum, while the exclusion of the duodenum and jejunum might be responsible for the down-regulation of GIP
Why this rating
Small sample size, but clear directional changes in hormones measured.
Source
Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery
Caterina Guidone et al. · Diabetes · 2006
DOI 10.2337/db06-0068
cohort · n=10Cited 367×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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