Hormonal
Leptin replacement therapy corrects metabolic anomalies (diabetes, dyslipidemia, hepatic steatosis) and reverses obesity in individuals with congenital leptin deficiency or lipodystrophy.
If you have a rare genetic condition causing leptin deficiency or lipodystrophy, leptin therapy is a highly effective, potentially curative treatment for your metabolic issues. However, if you are generally obese, your body likely already has high leptin levels but is resistant to them; taking leptin supplements will not work and is not recommended.
Leptin administration corrects many of the metabolic anomalies seen in lipodystrophic patients including diabetes, dyslipidemia, and hepatic steatosis (25, 26) and completely reverses the obese phenotype of leptin-deficient individuals (27, 28).
Why this rating
Supported by multiple human clinical studies cited (references 25-28) showing complete reversal of phenotype.
Source
Sixteen years and counting: an update on leptin in energy balance
Laurent Gautron et al. · Journal of Clinical Investigation · 2011
DOI 10.1172/jci45888
More from this paper
- In typical obesity, elevated leptin levels fail to suppress appetite or increase energy expenditure due to leptin resistance, and high-fat diets can exacerbate this resistance.Strong
- Central nervous system (CNS) leptin signaling is sufficient to regulate body weight, feeding, energy expenditure, and glucose metabolism, independent of peripheral leptin action.Good
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