Research
Hormonal
Central nervous system (CNS) leptin signaling is sufficient to regulate body weight, feeding, energy expenditure, and glucose metabolism, independent of peripheral leptin action.
Leptin works primarily in the brain, not directly on fat or muscle tissue, to control metabolism and blood sugar.
GoodSupportsHIGH confidence
studies in genetically modified mice have demonstrated that leptin action only in the CNS is sufficient to regulate body weight, feeding, energy expenditure, and glucose metabolism
Why this rating
Based on genetically modified mouse models (references 13, 19-21).
Source
Sixteen years and counting: an update on leptin in energy balance
Laurent Gautron et al. · Journal of Clinical Investigation · 2011
DOI 10.1172/jci45888
narrative_reviewCited 367×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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