Hormonal
Chronic mirabegron treatment improves insulin sensitivity, glucose effectiveness, and pancreatic beta-cell function in healthy women.
Mirabegron, taken at 100mg daily for 4 weeks, significantly improved insulin sensitivity and glucose handling in healthy women. This suggests beta-3 stimulation is a potent lever for metabolic health, though the high dose used here caused mild cardiovascular side effects, suggesting future drugs need better selectivity.
Whole-body insulin sensitivity (SI)... increased by 36%... Glucose effectiveness (SG)... increased by 34%... The disposition index (DI)... increased by 82%.
Why this rating
Same limitations as N1 (small n, no placebo), but measured via rigorous FSIGT testing.
Source
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
Alana O’Mara et al. · Journal of Clinical Investigation · 2020
DOI 10.1172/jci131126
More from this paper
- Chronic treatment with the beta-3 adrenergic receptor agonist mirabegron increases brown adipose tissue (BAT) metabolic activity and volume in healthy women without altering body weight.Moderate
- Chronic mirabegron treatment increases plasma levels of HDL cholesterol, ApoA1, and bile acids, independent of weight loss.Moderate
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