Research
Hormonal
Chronic mirabegron treatment increases plasma levels of HDL cholesterol, ApoA1, and bile acids, independent of weight loss.
Mirabegron treatment improved favorable lipid markers (HDL, ApoA1) and bile acids. This may be a downstream effect of increased brown fat activity consuming lipoproteins. This benefit occurred without weight loss.
ModerateSupportsMEDIUM confidence
We observed increased fasting levels of the following: HDL (+8%), apolipoprotein A1 (ApoA1) (+12%)... total bile acids (+49%).
Why this rating
Small sample size and lack of placebo control.
Source
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
Alana O’Mara et al. · Journal of Clinical Investigation · 2020
DOI 10.1172/jci131126
rct · n=14Cited 363×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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