Mixed
Positive airway pressure (PAP) therapy, including CPAP and ASV, does not reduce the risk of major adverse cardiovascular events (ACS, stroke, vascular death) or all-cause mortality in adults with sleep apnea compared to no treatment or sham.
If you have sleep apnea, use PAP to improve your sleep quality and daytime alertness, as it does provide symptomatic relief. However, do not rely on PAP alone to protect your heart or prevent death. You must still follow standard cardiovascular prevention guidelines, such as managing blood pressure, cholesterol, and using antiplatelet therapy if indicated.
The use of PAP, compared with no treatment or sham, was not associated with reduced risks of cardiovascular outcomes or death for patients with sleep apnea.
Why this rating
Based on a systematic review and meta-analysis of 10 randomized clinical trials involving 7,266 patients, providing high statistical power.
Source
Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea
Jie Yu et al. · JAMA · 2017
DOI 10.1001/jama.2017.7967
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