Research
Micronutrients & recovery
Long-term vitamin D supplementation does not reduce the risk of major adverse cardiovascular events (MACE), myocardial infarction, stroke, or all-cause mortality compared to placebo.
Based on this large meta-analysis, taking vitamin D supplements will not protect you from heart attacks, strokes, or early death, even if you have low levels. It is not indicated for cardiovascular prevention.
StrongRefutesVERY_HIGH confidence
Vitamin D supplementation compared with placebo was not associated with reduced major adverse cardiovascular events (RR, 1.00 [95% CI, 0.95-1.06]; P = .85) nor the secondary end points of myocardial infarction (RR, 1.00 [95% CI, 0.93-1.08]; P = .92), stroke (RR, 1.06 [95% CI, 0.98-1.15]; P = .16), CVD mortality (RR, 0.98 [95% CI, 0.90-1.07]; P = .68), or all-cause mortality (RR, 0.97 [95% CI, 0.93-1.02]; P = .23).
Why this rating
Meta-analysis of 21 randomized clinical trials with over 83,000 participants provides high-quality evidence.
Source
Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials
Mahmoud Barbarawi et al. · JAMA Cardiology · 2019
Meta-analysis · 21 studiesCited 362×
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