Research
Hormonal
IGF-1, HGF, and IL-6 are key regulators of satellite cell activation, proliferation, and differentiation in human skeletal muscle.
To optimize muscle growth, focus on exercises that stimulate the release of growth factors like IGF-1, HGF, and IL-6. This can be achieved through resistance training and a balanced diet.
GoodSupportsHIGH confidence
A number of growth factors and inflammatory cytokines released from skeletal muscle, surrounding cells and/or other tissues following exercise have been suggested to play a crucial role in satellite cell activation, proliferation, and/or differentiation during muscle fiber repair and remodeling in humans.
Why this rating
The paper reviews multiple studies showing the role of these regulators in satellite cell function.
Source
Satellite cells in human skeletal muscle plasticity
Tim Snijders et al. · Frontiers in Physiology · 2015
DOI 10.3389/fphys.2015.00283
narrative_reviewCited 354×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Skeletal muscle satellite cells are essential for muscle fiber repair and remodeling in response to exercise, with their activation, proliferation, and differentiation playing a key role in muscle adaptation.Good
- Aging has a profound impact on the regulation of satellite cells in human skeletal muscle, potentially leading to a decrease in satellite cell number and function.Good
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