Mixed

Combining moderate-to-vigorous exercise with GLP-1 receptor agonist (liraglutide) treatment preserves hip and lumbar spine bone mineral density (BMD) during significant weight loss, whereas GLP-1 RA treatment alone reduces BMD at these sites despite similar weight loss.

If you are using a GLP-1 medication like liraglutide or semaglutide for weight loss, you must incorporate regular exercise to protect your bones. This study shows that while the medication alone might reduce bone density at the hip and spine, adding moderate-to-vigorous exercise (like cycling and circuit training) completely preserves bone density, even when you lose a significant amount of weight. Do not rely on the medication alone for skeletal health.