Research
Hormonal
Administration of recombinant GDF15 reduces body weight and improves insulin sensitivity in obese models by increasing energy expenditure, lipid mobilization, and fatty acid oxidation in liver, muscle, and adipose tissue.
This research identifies GDF15 as a potent signal that triggers fat burning and energy use. While not a current supplement, it highlights that improving mitochondrial health in muscle may naturally boost this hormone, aiding weight management.
GoodSupportsHIGH confidence
In ob/ob mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue.
Why this rating
Strong evidence from multiple mouse models (MKO, POLG, ob/ob) and in vitro assays, though translational to humans is not directly tested.
Source
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Hyo Kyun Chung et al. · The Journal of Cell Biology · 2016
DOI 10.1083/jcb.201607110
mechanism_onlyCited 352×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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