Research
Hormonal
Skeletal muscle-specific deficiency in mitochondrial OxPhos (via Crif1 knockout) activates the UPRmt, leading to elevated GDF15 secretion, which protects against obesity and insulin resistance.
Maintaining muscle mitochondrial health may naturally upregulate GDF15, a hormone that helps regulate body weight and blood sugar.
StrongSupportsVERY_HIGH confidence
MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPRmt activation.
Why this rating
Extensive mechanistic validation including RNA-seq, knockout models, and in vitro pathways.
Source
Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
Hyo Kyun Chung et al. · The Journal of Cell Biology · 2016
DOI 10.1083/jcb.201607110
mechanism_onlyCited 352×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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